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Abstract #0871

Clinical application of ASL-based non-invasive perfusion territory mapping and time-resolved angiography in cerebrovascular diseases

Stephan Kaczmarz1, Miriam Reichert1, Moritz Roman Hernandez Petzsche1, Andreas Hock2, Kilian Weiss3, Kim van de Ven4, Christine Preibisch1, Jan Kirschke1, Claus Zimmer1, Makoto Obara5, Michael Helle6, Nico Sollmann1,7, and Hans Liebl1
1School of Medicine, Department of Neuroradiology, Technical University of Munich (TUM), Munich, Germany, 2Philips Healthcare, Horgen, Switzerland, 3Philips Healthcare, Hamburg, Germany, 4Philips Healthcare, Best, Netherlands, 5Philips Japan, Tokyo, Japan, 6University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany, 7Department of Radiology, University Ulm Medical Center, Ulm, Germany

Imaging of blood supply patterns is of high clinical interest to improve diagnostics in cerebrovascular diseases (CVD). However, the only clinically available imaging method is invasive digital subtraction angiography (DSA). We present data from 17 participants, including 7 CVD patients, with non-invasive MRI-based perfusion territory mapping by super-selective arterial spin labeling (ss-ASL) and time-resolved angiography by 4D-sPack with automated planning. Our results successfully confirmed automated planning even in CVD patients. Collateral pathways were non-invasively depicted by ss-ASL and 4D-sPack. Moreover, congruent results with DSA, contrast-enhanced MR-angiography and perfusion MRI demonstrated great potential for future routine application of ss-ASL and 4D-sPack.

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