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Abstract #0872

Application of MRI-based oxygen extraction fraction mapping in ischemic stroke

Di Wu1 and Shun Zhang1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

This study aims to investigate spatiotemporal evolution of cerebral oxygen extraction fraction (OEF) in ischemic stroke with an MRI-based vascular-challenge-free method. The OEF of the infarcted area descends continuously from acute to chronic phase. Meanwhile, there exists tissue that is likely to be penumbra in the acute diffusion lesion, of which the OEF shows an increasing trend with time, suggesting timely reperfusion in this region. This MRI-based OEF mapping can precisely capture the heterogenous character of brain oxygen metabolism at different phases of ischemic stroke.

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