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Abstract #0873

Prediction of Wallerian Degeneration in the Corticospinal Tract after Cerebral Ischemic Stroke: A Pilot APT and DWI Study

junxin wang1, yanwei Miao1, and Jiazheng Wang2
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Phillips healthcare, dalian, China

This study aimed to exploit the early Wallerian degeneration (WD) along the corticospinal tract following cerebral ischemic stroke using amide proton transfer weighted (APTw) and diffusion weighted imaging (DWI). This study included 34 patients with acute cerebral infarction and 21 healthy adult controls. Our data suggested that APTw and apparent diffusion coefficient (ADC) values was significantly increased on ipsilateral compared to contralateral and the control group in the posterior limb of internal capsule. It proves the feasibility of APTw and ADC in early detection of WD following cerebral ischemic stroke.

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