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Abstract #0874

Assessment of Symptom Onset Time in Ischemic Stroke Patients Using Fast High-Resolution 3D 1H-MRSI

Zengping Lin1, Tianyao Wang2, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Tianxiao Zhang1, Jun Liu2, Xin Yu5, Zhi-Pei Liang3,4, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Determination of ischemic stroke onset time is critical in ischemic stroke treatment. 1H-MRSI has been recognized as a potentially powerful tool for noninvasive metabolic imaging, which showed great promise for the assessment of stroke onset time. This study investigated changes of neurometabolite concentrations in lesion after different symptom onset time in ischemic stroke patients using a fast high-resolution 3D MRSI technique. Our results showed that NAA concentration within the ischemic lesion decreased in a time-dependent manner after stroke onset, which might provide a useful metabolic biomarker for assessment of symptom onset time.

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