Abstract #0875

Prediction of the Treatment Efficacy of Patients with Subacute Cerebral Infarction using the Heterogeneity of APT-weighted Signals

Yuhan Jiang¹, Peipei Chang¹, Yingqiu Liuyang¹, Bingbing Gao¹, Yiwei Che¹, Renwang Pu¹, Qingwei Song¹, Ailian Liu¹, Zhiwei Shen², Jiazheng Wang², and Yanwei Miao¹

¹the First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Philips Healthcare, Beijing, China

Amide proton transfer weighted (APTw) MRI has been increasingly applied in the study of stroke based on its ability to detect pH and intracellular proteins content. In subacute infarction, the heterogeneity of APTw signal may reflect the clinical treatment efficacy of patients. In this study, we found that there is negative correlation between the heterogeneity signals (APTw_max-min) in the ischemic regions and the difference of NIHSS scores on the day of hospital admission and leaving (∆NIHSS). Therefore, the heterogeneity of APTw signal is potentially an effective imaging biomarker to predict the efficacy of patients with subacute cerebral infarction.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.