Meeting Banner
Abstract #0878

Clinical Research of Multi-modal MRI in Ischemic Stroke: Cerebral Oxygen Extraction Fraction, Nonblood Susceptibility and Blood Flow

Di Wu1, Shun Zhang1, and Weiyin Vivian Liu2
1Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 2MR Research, GE Healthcare, Beijing, China, Beijing, China

This study aims to investigate oxygen metabolic, neuroinflammatory and hemodynamic parameters in different parts of the ischemic stroke lesions using multi-modal MRI. Significant difference of cerebral blood flow (CBF) was found between patients with and without penumbra. The oxygen extraction fraction (OEF) and nonblood susceptibility of tissue in the penumbra were significantly different from ischemic core, revealing benign oxygen metabolic compensation and less neuroinflammation in the penumbra. OEF in the diffusion lesion was positively correlated with clinical severity and continuously decreased with time. Multi-modal MRI-based markers can accurately reflect the pathophysiologic discrepancy in different regions of the ischemic stroke lesions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here