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Abstract #0877

Longitudinal Changes in Neurometabolite Levels from Acute to Subacute Stroke: A Pilot Study Using Fast High-resolution 3D 1H-MRSI

Bin Bo1, Tianyao Wang2, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Tianxiao Zhang1, Zengping Lin1, Ziyu Meng1, Jun Liu2, Xin Yu5, Zhi-Pei Liang3,4, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Detection of neurometabolic alterations in stroke patients from acute to subacute stages could provide useful information for brain tissue salvage therapy. Fast high-resolution 3D 1H-MRSI by SPICE has previously provided nearly whole-brain neurometabolic mapping in acute stroke patients. In this pilot study, we investigated the alterations of neurometabolites in a longitudinal cohort of ischemic stroke patients. Our preliminary results showed observable changes of different neurometabolites in different regions within the hypoperfused tissue of stroke patients from acute to subacute stages. Our study may lay a foundation for further investigation of temporal changes of neurometabolic biomarkers during stroke progression.

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