Abstract #0877

Longitudinal Changes in Neurometabolite Levels from Acute to Subacute Stroke: A Pilot Study Using Fast High-resolution 3D 1H-MRSI

Bin Bo¹, Tianyao Wang², Rong Guo^3,4, Yudu Li^3,4, Yibo Zhao^3,4, Tianxiao Zhang¹, Zengping Lin¹, Ziyu Meng¹, Jun Liu², Xin Yu⁵, Zhi-Pei Liang^3,4, and Yao Li¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Detection of neurometabolic alterations in stroke patients from acute to subacute stages could provide useful information for brain tissue salvage therapy. Fast high-resolution 3D ¹H-MRSI by SPICE has previously provided nearly whole-brain neurometabolic mapping in acute stroke patients. In this pilot study, we investigated the alterations of neurometabolites in a longitudinal cohort of ischemic stroke patients. Our preliminary results showed observable changes of different neurometabolites in different regions within the hypoperfused tissue of stroke patients from acute to subacute stages. Our study may lay a foundation for further investigation of temporal changes of neurometabolic biomarkers during stroke progression.

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