Meeting Banner
Abstract #0920

Multimodal molecular imaging assessment of changes in tumor microenvironment in response to combination of Evofosfamide and GEM

Yasunori Otowa1, Kota Yamashita1, Yu Saida1, Kazutoshi Yamamoto1, Jeffery R Brender1, Nallathamby Devasahayam1, Murali C. Krishna1, and Shun Kishimoto1
1National Cancer Institute, Bethesda, MD, United States

Combination of evofosfamide and chemotherapy suppress tumor growth than using these drugs alone. The purpose of this study is to detect physiologic changes in tumor-bearing mouse model in response to combination of evofosfamide and gemcitabine (GEM) using multi-modal imaging methods including DCE-MRI, blood volume imaging, and EPRI. Significantly increased perfusion, maintained blood volume, and maintained hypoxic fraction < 10 mmHg were observed after treatment with combination of evofosfamide and GEM. The results validate the utility of these imaging methods to non-invasively monitor changes in the tumor microenvironment after treatment.

This abstract and the presentation materials are available to members only; a login is required.

Join Here