Abstract #0921

Iron oxide-based Enzyme Mimic Nanocomposite for Dual-Modality Imaging Guided Chem-phototherapy and Anti-tumor Immunity Against Breast Cancer

Xiuhong Guan¹, Jiali Cai², Xiangyu Xiong¹, Hong Liu², Shihui Huang², Sheng Wang², Chuanqi Sun¹, Yi Sun³, Tianjing Zhang⁴, Guoxi Xie¹, and Zhiyong Wang²

¹Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China, ²School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, China, ³Siemens Healthineers, Shanghai, China, ⁴Philips Healthcare, Guangzhou, China

Due to the high incidence and mortality, breast cancer has become the major cause of cancer death among female. This study reports a kind of functional nanocomposite, which was designed to comprises Pluronic P123 to self-assembly superparamagnetic iron oxide nanocrystals (SPIONs) and IR-780 dyes into one system, exhibiting NIR-II and MR dual-modal imaging guided chem-phototherapy and anti-tumor immunity against triple-negative breast cancer.

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