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Abstract #0921

Iron oxide-based Enzyme Mimic Nanocomposite for Dual-Modality Imaging Guided Chem-phototherapy and Anti-tumor Immunity Against Breast Cancer

Xiuhong Guan1, Jiali Cai2, Xiangyu Xiong1, Hong Liu2, Shihui Huang2, Sheng Wang2, Chuanqi Sun1, Yi Sun3, Tianjing Zhang4, Guoxi Xie1, and Zhiyong Wang2
1Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China, 2School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, China, 3Siemens Healthineers, Shanghai, China, 4Philips Healthcare, Guangzhou, China

Due to the high incidence and mortality, breast cancer has become the major cause of cancer death among female. This study reports a kind of functional nanocomposite, which was designed to comprises Pluronic P123 to self-assembly superparamagnetic iron oxide nanocrystals (SPIONs) and IR-780 dyes into one system, exhibiting NIR-II and MR dual-modal imaging guided chem-phototherapy and anti-tumor immunity against triple-negative breast cancer.

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