The liver is the most common organ for metastasis of various malignancies, especially for uveal melanoma (UM), colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). Precision medicine to chronic diseases, especially for liver cancer and metastasis, requires non-invasive precision diagnostics. Non-invasive precision imaging capable of early detection, staging and molecular subtyping/stratification of patients, is a major breakthrough. Rapid development and approval of precision medicine also requires precision imaging to evaluate drug efficacy at animal and patient levels. There is a pressing unmet medical need to develop MRI contrast agents and imaging methodologies with desired sensitivity and specificity .