Abstract #0924

3D Free-breathing Multitasking T1-T2 Mapping in Small Animals on a 3-Tesla System: A Preliminary Study on a Murine Model with Liver Metastasis

Nan Wang¹, Jingjuan Qiao², Zhijun Wang³, Pei Han^1,4, Hsu-Lei Lee¹, Sen Ma¹, Hui Han¹, Zhaoyang Fan¹, Anthony G. Christodoulou¹, Ekihiro Seki³, Stephen Pandol⁵, Debiao Li¹, Jenny Yang², and Yibin Xie¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Chemistry Department, Georgia State University, Atlanta, GA, United States, ³Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ⁵Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, United States

MRI is a promising tool for the non-invasive study of animal model, but continues to face technical challenges. In this work, a Multitasking T1-T2 mapping technique was proposed for mouse abdominal imaging on 3T, which achieved 3D coverage, motion-resolved acquisition, and simultaneous T1 T2 mapping within 10 minutes. The study was performed on a murine model with liver metastasis of colorectal cancer. Data at multiple time points after tumor injection were acquired with different contrast agent, Eovist and ProCA.collagen1. The results demonstrated that 10-min Multitasking technique produced improved images with clear tumor delineation compared to conventional MRI series (50 minutes).

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