Deuterium Metabolic Imaging (DMI) was used to follow metabolism in two pancreatic cancer mouse models, after tail-vein administration of 2H6,6’-glucose. Metabolic maps for the glucose and for its metabolic products 2H3,3’-lactate and 2H-water were measured over a time course of 2 h by 2H chemical shift imaging (CSI) at 15.2 T. Abdominal images exhibited sharp and specific lactate signals, which generated exclusively in the tumors. Thus, DMI may open valuable opportunities for non-invasively imaging pancreatic cancer –including its diagnosis and treatment.
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