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Abstract #0925

Deuterium metabolic imaging (DMI) of glucose highlights pancreatic cancers in two mice models

Stefan Markovic1, Tangi Roussel2, Keren Sasson3, Dina Preise3, Lilach Agemi3, Avigdor Scherz3, and Lucio Frydman1
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Center for Magnetic Resonance in Biology and Medicine, Marseille, France, 3The Moross Integrated Cancer Research Center, Weizmann Institute of Science, Rehovot, Israel

Deuterium Metabolic Imaging (DMI) was used to follow metabolism in two pancreatic cancer mouse models, after tail-vein administration of 2H6,6’-glucose. Metabolic maps for the glucose and for its metabolic products 2H3,3’-lactate and 2H-water were measured over a time course of 2 h by 2H chemical shift imaging (CSI) at 15.2 T. Abdominal images exhibited sharp and specific lactate signals, which generated exclusively in the tumors. Thus, DMI may open valuable opportunities for non-invasively imaging pancreatic cancer –including its diagnosis and treatment.

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