Abstract #0927

Comparison of Tumour pH Environment and Glycolysis Measurements in a C6 Rat Model of Glioma

Qi Qi^1,2,3, Matthew Fox^1,4, Robert Bartha^2,5,6, Miranda Bellyou⁵, Lise Desjardins⁷, Lisa Hoffman^1,2,8, Alex Li⁵, Andrew McClennan^1,2, Ting Yim Lee^1,2,3,5,6, and Jonathan D Thiessen^1,2,3,6

¹Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Molecular Imaging, Western University, London, ON, Canada, ⁴Physics and Astronomy, Western University, London, ON, Canada, ⁵Robart Research Institute, London, ON, Canada, ⁶Medical Imaging, Western University, London, ON, Canada, ⁷Lawson Health Research Institute, London, ON, Canada, ⁸Anatomy and Cell Biology, Western University, London, ON, Canada

There is an intrinsic relationship between tumour glycolysis and its pH environment. CEST MRI enables the detection of tumour pH in both intra- (pH_i) and extracellular (pH_e) spaces with AACID and acidoCEST methods. Kinetic analysis of dynamic FDG-PET can provide an accurate measurement of tumour glycolysis. This study demonstrates the capability of simultaneous measurements of pH_i and pH_e using CEST MRI, providing a more complete picture of the tumour pH environment, and explores the intrinsic relationship between tumour glycolysis and its pH environment.

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