Cramer-Rao lower bound (CRLB) is commonly employed as an exclusion criterion for bad quality MR spectra. This study aims to investigate the CRLB differences of the metabolites between isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase promoter (TERTp) mutational subgroups in gliomas, and to assess the effects of CRLB threshold on their classifications. GPC, PCh, 2HG, and Ins were more reliably detected in IDH-mutant gliomas. Ins had higher CRLB values in TERTp-mutant than TERTp-wildtype gliomas. Different CRLB thresholds followed by zero-imputing had a small impact on the classification accuracies, but affected the choice of best features and classification algorithms.
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