Meningiomas are a heterogeneous group of tumors that arise at the pachymeninges and tend to invade surrounding bone and rarely the brain. In this work, we studied the single-voxel 1H-MRS correlates of aggressive biology (measured by WHO grade), peritumoral edema, brain invasion, bone invasion, skull base location in meningiomas. Higher Glyc and Ins+Glyc levels were observed in aggressive (WHO grade II or III) meningiomas. Higher Glu, GPC, and Glx levels were observed in hyperostotic tumors. The classification accuracies were 81.28% for tumor grade, 73.18% for hyperostosis detection, and 76.88% for skull base localization of meningiomas.
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