Abstract #0955

Early detection of radiation-induced injury and prediction of cognitive deficit by MRS metabolites in radiotherapy of low grade glioma

Zahra Alirezaei^1,2, Mohammadreza Nazemzadeh³, Masoud Hasanpour³, Alireza Amouheidari⁴, and Sajad Iraji³

¹Isfahan University of Medical Sciences, Isfahan, Iran (Islamic Republic of), ²Bushehr University of Medical Sciences, Bushehr, Iran (Islamic Republic of), ³Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁴Milad Hospital, Isfahan, Iran (Islamic Republic of)

To compare the sensitivity of alteration in MRS metabolites and MoCA and ACE-R cognitive tests in early and early-delayed post-radiation phases in detection of radiation-induced injury of Low Grade Glioam patients. The MRS metabolites, the ACE-R and MoCA, and the dosimetric parameters in the corpus callosum were analyzed during RT and up to 6-month post-RT for 10 LGG patients. NAA/Cr and Cho/Cr declined significantly at least 3 months before detecting alterations in ACE and MoCA cognitive tests. Therefore, the MRS-based biomarkers may be more sensitive than the state of the art cognitive test tools in prediction of post-radiation cognitive impairments.

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