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Abstract #0955

Early detection of radiation-induced injury and prediction of cognitive deficit by MRS metabolites in radiotherapy of low grade glioma  

Zahra Alirezaei1,2, Mohammadreza Nazemzadeh3, Masoud Hasanpour3, Alireza Amouheidari4, and Sajad Iraji3
1Isfahan University of Medical Sciences, Isfahan, Iran (Islamic Republic of), 2Bushehr University of Medical Sciences, Bushehr, Iran (Islamic Republic of), 3Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 4Milad Hospital, Isfahan, Iran (Islamic Republic of)

To compare the sensitivity of alteration in MRS metabolites and MoCA and ACE-R cognitive tests in early and early-delayed post-radiation phases in detection of radiation-induced injury of Low Grade Glioam patients. The MRS metabolites, the ACE-R and MoCA, and the dosimetric parameters in the corpus callosum were analyzed during RT and up to 6-month post-RT for 10 LGG patients. NAA/Cr and Cho/Cr declined significantly at least 3 months before detecting alterations in ACE and MoCA cognitive tests. Therefore, the MRS-based biomarkers may be more sensitive than the state of the art cognitive test tools in prediction of post-radiation cognitive impairments.

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