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Abstract #0956

31P spectral profiles in brain tissues of volunteers and glioma patients at 7T

Andreas Korzowski1, Nina Weckesser2, Vanessa L Franke1, Heinz-Peter Schlemmer2, Mark E Ladd1, Peter Bachert1, and Daniel Paech2
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

The low spatial resolution of 31P MRSI of the human brain leads to a weighted mixture of specific spectral profiles from different tissue types in localized 31P spectra of individual voxels. Application of high-resolution 31P MRSI to volunteers and glioma patients at ultra-high B0 yields a possibility to approach brain tissue-specific profiles, which could aid interpretation of observations from 31P MRSI. The presented high-quality 31P brain spectra from individual tissue types obtained at B0 = 7T illustrate clear differences not only between healthy and tumor tissues, but also between different compartments within diseased tissue, i.e. contrast-enhanced regions and edema.

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