The low spatial resolution of 31P MRSI of the human brain leads to a weighted mixture of specific spectral profiles from different tissue types in localized 31P spectra of individual voxels. Application of high-resolution 31P MRSI to volunteers and glioma patients at ultra-high B0 yields a possibility to approach brain tissue-specific profiles, which could aid interpretation of observations from 31P MRSI. The presented high-quality 31P brain spectra from individual tissue types obtained at B0 = 7T illustrate clear differences not only between healthy and tumor tissues, but also between different compartments within diseased tissue, i.e. contrast-enhanced regions and edema.
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