Abstract #0981

Cardiovascular magnetic resonance T1ρ endogenous contrast can detect early myocardial fibrosis in hypertrophic cardiomyopathy

Keyan Wang¹, Jingliang Cheng², Yang Yang³, and Jie Zheng⁴

¹MRI, 1st Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²1st Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Mallinckrodt Institute of Radiology, Washington University in St, Washington, WA, United States

The study is to determine clinical utility of T1ρ to detect myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) at different subtypes. The results showed that absolute T1ρ (ms) increased progressively and significantly from volunteer to HCM-N and then to HCM-H. ECV has the same trend as T1ρ. There was a strong positive correlation between ECV and T1ρ. If selecting T1ρ relaxation times of 36.5ms as the cutoff value for normal myocardial fibrosis, the sensitivity, specificity and AUC to detect myocardial fibrosis were 83.7%, 91.3%, and 0.937, respectively.T1ρ is able to detect early diffuse fibrosis in HCM and two subtypes.

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