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Abstract #0982

Diffusion Tensor Imaging Reveals Myocardial Structure after Stem Cell-derived Cardiomyocyte Therapy in Myocardial Infarction

Moses P. Cook1, Wahiba Dhahri2, Graham A. Wright1,3,4, Michael A. Laflamme2, and Nilesh R. Ghugre1,3,4
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, Canada, 3Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada

Cardiac regenerative therapies using pluripotent stem cell-derived cardiomyocytes (PSC-CM, the graft) have shown promise in animal models of myocardial infarction. However, the mechanisms of structural integration of graft with host myocardium and the associated impact on function are less understood. 3D Diffusion Tensor Imaging (DTI) and contrast enhanced MRI were performed at 7T in ex vivo guinea pig hearts to quantify cardiac microstructure post PSC-CM transplantation. DTI parameters within the graft trended towards the healthy non-infarcted state, demonstrating a degree of anisotropic tissue repopulation within the infarct zone. MRI is a valuable marker for treatment efficacy in emerging regenerative therapies.

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