Abstract #0982

Diffusion Tensor Imaging Reveals Myocardial Structure after Stem Cell-derived Cardiomyocyte Therapy in Myocardial Infarction

Moses P. Cook¹, Wahiba Dhahri², Graham A. Wright^1,3,4, Michael A. Laflamme², and Nilesh R. Ghugre^1,3,4

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, Canada, ³Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada

Cardiac regenerative therapies using pluripotent stem cell-derived cardiomyocytes (PSC-CM, the graft) have shown promise in animal models of myocardial infarction. However, the mechanisms of structural integration of graft with host myocardium and the associated impact on function are less understood. 3D Diffusion Tensor Imaging (DTI) and contrast enhanced MRI were performed at 7T in ex vivo guinea pig hearts to quantify cardiac microstructure post PSC-CM transplantation. DTI parameters within the graft trended towards the healthy non-infarcted state, demonstrating a degree of anisotropic tissue repopulation within the infarct zone. MRI is a valuable marker for treatment efficacy in emerging regenerative therapies.

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