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Abstract #0992

Free-Breathing High-Resolution Quantitative First-Pass Perfusion Cardiac MR using Dual-Echo Dixon

Cian Scannell1, Torben Schneider2, Ebraham Alskaf1, Filippo Bosio1, Joao Tourais3, Javier Sanchez-Gonzalez4, Mariya Doneva5, Christophe Schuelke5, Jakob Meineke5, Jochen Keupp5, Jouke Smink6, Marcel Breeuwer7, Amedeo Chiribiri1, Markus Henningsson8,9, and Teresa M Correia1
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Philips Healthcare, Guildford, United Kingdom, 3Magnetic Resonance Systems Lab, Delft University of Technology, Delft, Netherlands, 4Philips Healthcare Iberia, Madrid, Spain, 5Philips Research, Hamburg, Germany, 6MR Clinical Science, Philips Healthcare, Best, Netherlands, 7Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 8Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, 9Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden

First-pass perfusion cardiac MR (FP-CMR) is an essential tool for characterizing ischemic heart disease. Moreover, automated quantitative methods enable a reliable and operator-independent assessment of myocardial blood flow. Conventional FP-CMR has limited spatial resolution and is performed under breath-hold. Therefore, diagnostic accuracy is compromised by respiratory induced motion artifacts and false-positives due to dark-rim artifacts. To overcome these challenges, free-breathing Fat-water separation for mOtion-corrected Spatio-TEmporally accelerated myocardial peRfuSion (FOSTERS) has been proposed. Here, we implement and evaluate a high-resolution dual-echo Dixon version of FOSTERS and compare its quantitative performance to standard-resolution FP-CMR in patients with suspected cardiovascular disease.

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