Abstract #0992

Free-Breathing High-Resolution Quantitative First-Pass Perfusion Cardiac MR using Dual-Echo Dixon

Cian Scannell¹, Torben Schneider², Ebraham Alskaf¹, Filippo Bosio¹, Joao Tourais³, Javier Sanchez-Gonzalez⁴, Mariya Doneva⁵, Christophe Schuelke⁵, Jakob Meineke⁵, Jochen Keupp⁵, Jouke Smink⁶, Marcel Breeuwer⁷, Amedeo Chiribiri¹, Markus Henningsson^8,9, and Teresa M Correia¹

¹School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Philips Healthcare, Guildford, United Kingdom, ³Magnetic Resonance Systems Lab, Delft University of Technology, Delft, Netherlands, ⁴Philips Healthcare Iberia, Madrid, Spain, ⁵Philips Research, Hamburg, Germany, ⁶MR Clinical Science, Philips Healthcare, Best, Netherlands, ⁷Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁸Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ⁹Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden

First-pass perfusion cardiac MR (FP-CMR) is an essential tool for characterizing ischemic heart disease. Moreover, automated quantitative methods enable a reliable and operator-independent assessment of myocardial blood flow. Conventional FP-CMR has limited spatial resolution and is performed under breath-hold. Therefore, diagnostic accuracy is compromised by respiratory induced motion artifacts and false-positives due to dark-rim artifacts. To overcome these challenges, free-breathing Fat-water separation for mOtion-corrected Spatio-TEmporally accelerated myocardial peRfuSion (FOSTERS) has been proposed. Here, we implement and evaluate a high-resolution dual-echo Dixon version of FOSTERS and compare its quantitative performance to standard-resolution FP-CMR in patients with suspected cardiovascular disease.

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