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Abstract #0997

Extracellular Volume Fraction Mapping May Distinguish Acute Pediatric Heart Transplant Rejection from Non-Rejection

Bruce Damon1, Margaret M. Samyn2, Ke Yan2, Aryaz Sheybani3, Wubishet Belay3, Justin Godown3, Lazaro Hernandez4, Kristen George-Durrett3, and Jonathan Soslow3
1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States, 3Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, United States, 4Pediatric Cardiology, Joe DiMaggio Children’s Hospital, Hollywood, FL, United States

Acute rejection (AR) remains a significant cause of morbidity and mortality in pediatric patients after heart transplant. Endomyocardial biopsy (EMB) of the right ventricular septum is the standard method for diagnosing AR. However, EMB is prone to additional risk and sampling error as AR is a heterogeneous process. Here we show that extracellular volume fraction (ECV) mapping of the left ventricle (LV) analyzed with standard descriptive statistics and specialized texture analysis may differentiate pediatric heart transplant recipients as having AR or not. This CMR diagnostic approach offers diagnostic advantages including greater sampling volume and minimal invasiveness.

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