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Abstract #0996

Assessment of Cardiovascular Characterization in Rat Model of non-Targeted Heart Radiation Using MRI

El-Sayed H Ibrahim1, Marek Lenarczyk1, and John Baker1
1Medical College of Wisconsin, Milwaukee, WI, United States

The effect of exposure outside of the geometric radiation field on non-targeted organs as it results in cardiac disease is uncertain. Characterization of myocardial tissue abnormalities and cardiac dysfunction with cardiac MRI represents a valuable tool to define the presence and stage of a disorder at given timepoint. In this study, cardiac MRI was performed in an established rat model of irradiation injury to the non-targeted heart at different timepoints post irradiation. The results showed the value of myocardial strain and T1 measurements as sensitive markers of cardiovascular changes due to non-direct irradiation effect on the heart.

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