Abstract #0999

In vivo MR elastography of the murine hippocampus is sensitive to the microscopic mechanical properties of dentate gyrus subzones

Anna Morr¹, Marcin Nowicki², Gergely Bertalan¹, Rafaela Vieira da Silva¹, Carmen Infante Duarte¹, Stefan Paul Koch¹, Philipp Boehm-Sturm¹, Ute Krügel², Jürgen Braun¹, Barbara Steiner¹, Josef Käs², Thomas Fuhs², and Ingolf Sack¹

¹Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Universität Leipzig, Leipzig, Germany

In this study, we investigated the mechanical properties of subregions of the murine dentate gyrus in vivo using MR elastography (MRE) and ex vivo with atomic force microscopy (AFM). Consistent with AFM, subregional analysis of the dentate gyrus by MRE revealed that the subgranular zone (SGZ), in which adult neurogenesis takes place, is characterized by marked soft-solid properties. We conclude that MRE is sensitive to micromechanical properties beyond the image resolution. The observed soft-solid material properties of the SGZ quantified by AFM and MRE might be of functional relevance for neurogenesis in the mouse brain.

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