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Abstract #0999

In vivo MR elastography of the murine hippocampus is sensitive to the microscopic mechanical properties of dentate gyrus subzones

Anna Morr1, Marcin Nowicki2, Gergely Bertalan1, Rafaela Vieira da Silva1, Carmen Infante Duarte1, Stefan Paul Koch1, Philipp Boehm-Sturm1, Ute Krügel2, Jürgen Braun1, Barbara Steiner1, Josef Käs2, Thomas Fuhs2, and Ingolf Sack1
1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Universität Leipzig, Leipzig, Germany

In this study, we investigated the mechanical properties of subregions of the murine dentate gyrus in vivo using MR elastography (MRE) and ex vivo with atomic force microscopy (AFM). Consistent with AFM, subregional analysis of the dentate gyrus by MRE revealed that the subgranular zone (SGZ), in which adult neurogenesis takes place, is characterized by marked soft-solid properties. We conclude that MRE is sensitive to micromechanical properties beyond the image resolution. The observed soft-solid material properties of the SGZ quantified by AFM and MRE might be of functional relevance for neurogenesis in the mouse brain.

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