Abstract #1000

Are multiple sclerosis lesions stiffer or softer than surrounding brain tissue?

Helge Herthum¹, Stefan Hetzer², Michael Scheel¹, Friedemann Paul³, Heiko Tzschätzsch¹, Tom Meyer¹, Mehrgan Shahryari¹, Jürgen Braun⁴, and Ingolf Sack¹

¹Experimentelle Radiologie, Charité Universitätsmedizin Berlin, Berlin, Germany, ²Berlin Center for Advanced Neuroimaging (BCAN), Berlin, Germany, ³NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Berlin, Germany, ⁴Institut für medizinische Informatik, Charité Universitätsmedizin Berlin, Berlin, Germany

Using multifrequency MR elastography with 2- and 1.5mm resolutions in a cohort of 19 patients with multiple sclerosis and a total 206 analyzed lesions we found no evidence for systematic differences in the viscoelastic properties between MS lesions and surrounding brain tissue. Although future technical improvements in MRE resolution and parameter reconstruction methods might reveal significant differences between lesion and brain properties, our results indicate that those differences are minor compared to other published changes in brain viscoelasticity of the human brain.

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