Abstract #1006

Assessment of Obesity-Related Inflammation in Subcutaneous Adipose Tissue with MR Elastography (MRE)

Jiahui Li¹, Prachi Singh², Marzanna Obrzut¹, Xin Lu¹, Kevin J. Glaser¹, Alina Allen³, Sudhakar K. Venkatesh¹, Taofic Mounajjed⁴, Jun Chen¹, Armando Manduca¹, Vijay Shah³, Richard L. Ehman¹, and Meng Yin¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Sleep and Cardiometabolic Health, Pennington Biomedical Research Center, Baton Rouge, LA, United States, ³Gastroenterology, Mayo Clinic, Rochester, MN, United States, ⁴Anatomic Pathology, Mayo Clinic, Rochester, MN, United States

Multiparametric MRI and MRE was performed in 27 obese patients who had biopsies of liver and subcutaneous adipose tissues. We found significant correlations between the mechanical properties of liver and subcutaneous fat and their histological and biochemistry results. A model combining liver proton density fat fraction and subcutaneous fat stiffness had a slightly higher AUC for diagnosing nonalcoholic steatohepatitis than liver stiffness (AUC: 0.87 vs. 0.84, p=0.74). The results indicate that obesity-induced systemic inflammation affects both adipose and liver tissue mechanical properties and, therefore, models utilizing mechanical biomarkers from adipose tissue may improve the diagnosis of steatohepatitis in obese patients.

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