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Abstract #1005

Viscoelastic Differences in Human Gray and White Matter at Different Spatial Resolutions

Shruti Mishra1,2, Bin Deng2,3,4, W. Scott Hoge1,2,3, Giacomo Annio5, Ralph Sinkus5, and Samuel Patz1,2
1Department of Radiology, Brigham & Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Athinoula A. Marginos Center for Biomedical Imaging, Charlestown, MA, United States, 4Radiology, Massachusetts General Hospital, Boston, MA, United States, 5Laboratory for Vascular Translational Science (LVTS), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France

Magnetic resonance elastography (MRE) was utilized to demonstrate differences in shear wavelength between human cortical gray matter and subcortical white matter and evaluate the effect of spatial resolution on wavelength estimation. Much greater brain architectural detail was discerned in the viscoelastic maps when going from 2.5 mm to 1.5 mm isotropic spatial resolution. We also demonstrate in individual healthy subjects, through two adjacent multi-voxel regions of interest, that cortical gray matter is stiffer than adjacent subcortical white matter, and that this difference is accentuated at higher resolutions. Furthermore, we show that the mean estimated wavelength increases with decreasing spatial resolution.

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