Magnetic resonance elastography (MRE) was utilized to demonstrate differences in shear wavelength between human cortical gray matter and subcortical white matter and evaluate the effect of spatial resolution on wavelength estimation. Much greater brain architectural detail was discerned in the viscoelastic maps when going from 2.5 mm to 1.5 mm isotropic spatial resolution. We also demonstrate in individual healthy subjects, through two adjacent multi-voxel regions of interest, that cortical gray matter is stiffer than adjacent subcortical white matter, and that this difference is accentuated at higher resolutions. Furthermore, we show that the mean estimated wavelength increases with decreasing spatial resolution.
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