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Abstract #1004

MR elastography of abdominal aortic aneurysm specimens

Dilyana B. Mangarova1,2, Julia Brangsch1, Marcus R. Makowski1,3, Bernd Hamm1, Ingolf Sack1, Jürgen Braun 4, and Gergely Bertalan1
1Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Veterinary Pathology, Free University of Berlin, Berlin, Germany, 3Department of Diagnostic and Interventional Radiology, Technical University of Munich, Berlin, Germany, 4Institute for Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Abdominal aortic aneurysms (AAA) are among the worldwide leading causes of death. Standard MRI and ultrasonography cannot predict the risk of life-threatening AAA rupture. The ECM composition and therefore the stiffness of the aortic wall changes during AAA development and progression. Therefore, we investigated AAA stiffness in murine tissue samples using MR elastography with an in-plane resolution of 40 microns. Compared to healthy aorta, we found an increase of vessel wall stiffness in AAA of approximately 20% and an excellent correlation of histology-quantified ECM accumulation with thrombus stiffness.

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