We aimed to evaluate the heterogeneity of viscoelastic tissue properties of fresh prostatectomy specimens of men with prostate cancer using MR elastography and histopathology as a reference. Our results suggest that prostate cancer is characterized by a stiff yet homogeneous biomechanical signature. A possible explanation for this finding might be differences of healthy vs. cancerous tissue based on anatomical zones and their specific nonmalignant pathologies (prostatitis in the peripheral zone and benign prostatic hyperplasia in the central gland), and the unique nondestructive growth pattern of PC with intervening stroma which might provide a rigid scaffold.
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