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Abstract #1002

Micro MR elastography of the zebrafish brain

Jakob Jordan1, Gergely Bertalan1, Heiko Tzschätzsch1, Tom Meyer1, Anton Gauert2, Anja Heeren-Hagemann2, Jürgen Braun3, and Ingolf Sack1
1Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Hematology/Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Institute of Medical Informatic, Charité - Universitätsmedizin Berlin, Berlin, Germany

Zebrafish have emerged as a versatile, cost-efficient and easy-to-handle animal model in many areas of biomedical research. Using multifrequency MR elastography at 7-Tesla and 1000 to 1400 Hz excitation frequency, we analyzed the viscoelastic properties of the post-mortem zebrafish brain. Shear wave speed as a surrogate marker of stiffness was mapped with an in-plane resolution of 40 microns showing stiffer properties (1.2±0.3 m/s) of the brain than skeletal muscle (0.89±0.09 m/s). Furthermore, sub-regions showed distinct stiffness properties, which, however, lacked significance in this preliminary feasibility study.

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