Abstract #1009

3D-MRE as independent predictor of direct portal venous pressure compared to Biopsy derived Fibrosis Measurements

Giacomo Annio^1,2, Ahmed Hamimi³, Khaled Z. Abd-Elmoniem ³, Theo Heller³, Elliot Levy ³, David E. Kleiner⁴, Ohad Etzion⁵, Rabab Ali⁶, Ralph Sinkus^1,2, and Ahmed M. Gharib³

¹LVTS, INSERM U1148, Paris, France, ²Department of Biomedical Engineering, King's College London, London, United Kingdom, ³Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, ⁴Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, ⁵Department of Gastroenterology and Liver Diseases, Ben-Gurion University of the Negev, Be'er Sheva, Israel, ⁶Department of Internal Medicine, Duke University, Durham, NC, United States

The assessment of liver fibrosis and inflammation is crucial to the clinical management of patients suffering from liver diseases. Portal venous pressure assessment has important prognostic implications for hepatic disease patients’ care. However, it can only be measured invasively. In this work we show that liver stiffness quantified via 3DMRE is a strong independent predictor of DPVP compared to invasive biopsy. Moreover stiffness as evaluated with 3DMRE is an operator independent and non-invasive biomarker which could hence constitute an optimal method for diagnosis and fibrosis staging in all patients and a non-invasive surrogate of DPVP.

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