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Abstract #1009

3D-MRE as independent predictor of direct portal venous pressure compared to Biopsy derived Fibrosis Measurements  

Giacomo Annio1,2, Ahmed Hamimi3, Khaled Z. Abd-Elmoniem 3, Theo Heller3, Elliot Levy 3, David E. Kleiner4, Ohad Etzion5, Rabab Ali6, Ralph Sinkus1,2, and Ahmed M. Gharib3
1LVTS, INSERM U1148, Paris, France, 2Department of Biomedical Engineering, King's College London, London, United Kingdom, 3Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, 4Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, 5Department of Gastroenterology and Liver Diseases, Ben-Gurion University of the Negev, Be'er Sheva, Israel, 6Department of Internal Medicine, Duke University, Durham, NC, United States

The assessment of liver fibrosis and inflammation is crucial to the clinical management of patients suffering from liver diseases. Portal venous pressure assessment has important prognostic implications for hepatic disease patients’ care. However, it can only be measured invasively. In this work we show that liver stiffness quantified via 3DMRE is a strong independent predictor of DPVP compared to invasive biopsy. Moreover stiffness as evaluated with 3DMRE is an operator independent and non-invasive biomarker which could hence constitute an optimal method for diagnosis and fibrosis staging in all patients and a non-invasive surrogate of DPVP.

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