The assessment of liver fibrosis and inflammation is crucial to the clinical management of patients suffering from liver diseases. Portal venous pressure assessment has important prognostic implications for hepatic disease patients’ care. However, it can only be measured invasively. In this work we show that liver stiffness quantified via 3DMRE is a strong independent predictor of DPVP compared to invasive biopsy. Moreover stiffness as evaluated with 3DMRE is an operator independent and non-invasive biomarker which could hence constitute an optimal method for diagnosis and fibrosis staging in all patients and a non-invasive surrogate of DPVP.