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Abstract #1023

Magnetic resonance elastography of the in vivo human brain using multifrequency wavenumber analysis in 2D and 3D.

Helge Herthum1, Heiko Tzschätzsch1, Tom Meyer1, Mehrgan Shahryari1, Lisa Stencel1, Jing Guo1, Jürgen Braun2, and Ingolf Sack1
1Experimentelle Radiologie, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Institut für medizinische Informatik, Charité Universitätsmedizin Berlin, Berlin, Germany

Wavenumber analyses in MR elastography (MRE), which use first-order finite difference operators, are known to be more stable against noise than second-order finite derivative methods. However, wavenumber analyses for the human brain normally suffer from abundant heterogeneities and solid-fluid interfaces. We here present multifrequency wavenumber analysis for MRE of the human brain in 2D and 3D based on adapted bandpass filters. We show that both approaches provide better repeatability in test-retest experiments compared to standard analyses. Moreover, wavenumber analyses yield stable values and rich detail in regions of lower signal-to-noise-ratio such as deep gray matter.

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