Abstract #1026

Cerebral inversion recovery MR elastography for cortical stiffness quantification

Ledia Lilaj¹, Helge Herthum², Tom Meyer², Mehrgan Shahryari², Gergely Bertalan², Alfonso Caiazzo², Jürgen Braun³, Thomas Fischer², Sebastian Hirsch^4,5, and Ingolf Sack²

¹Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Charité – Universitätsmedizin Berlin, Berlin, Germany, ³Institute of Medical Informatics, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴Berlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁵Bernstein Center for Computational Neuroscience, Berlin, Germany

Inversion recovery magnetic resonance elastography (IR-MRE) is a new acquisition technique that performs MRE while selectively nulling the signal generated by one compartment with a specific T1. In phantom and in vivo experiments, free fluid, water or cerebrospinal fluid, was nulled. The shear wave speed (SWS) maps showed no overall change in average values. However, in cortical areas, IR-MRE revealed cortical SWS values 10% higher than in standard MRE, resulting in sharper tissue-CSF interfaces. Besides, ventricles are 39% narrower in IR-MRE than in MRE. In conclusion, IR-MRE allows a more precise quantification of cortical stiffness.

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