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Abstract #1026

Cerebral inversion recovery MR elastography for cortical stiffness quantification

Ledia Lilaj1, Helge Herthum2, Tom Meyer2, Mehrgan Shahryari2, Gergely Bertalan2, Alfonso Caiazzo2, Jürgen Braun3, Thomas Fischer2, Sebastian Hirsch4,5, and Ingolf Sack2
1Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Institute of Medical Informatics, Charité – Universitätsmedizin Berlin, Berlin, Germany, 4Berlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, Berlin, Germany, 5Bernstein Center for Computational Neuroscience, Berlin, Germany

Inversion recovery magnetic resonance elastography (IR-MRE) is a new acquisition technique that performs MRE while selectively nulling the signal generated by one compartment with a specific T1. In phantom and in vivo experiments, free fluid, water or cerebrospinal fluid, was nulled. The shear wave speed (SWS) maps showed no overall change in average values. However, in cortical areas, IR-MRE revealed cortical SWS values 10% higher than in standard MRE, resulting in sharper tissue-CSF interfaces. Besides, ventricles are 39% narrower in IR-MRE than in MRE. In conclusion, IR-MRE allows a more precise quantification of cortical stiffness.

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