Abstract #1027

Multi-Excitation Actuator Design for Anisotropic Brain MRE

Diego A. Caban-Rivera¹, Daniel R. Smith¹, Keshav A. Kailash², Ruth J. Okamoto², Matthew D.J. McGarry ³, Lance T. Williams¹, Charlotte Guertler², Grace Mcilvain¹, Damian Sowinski³, Elijah E.W. Van Houten ⁴, Keith D. Paulsen^3,5, Philip V. Bayly², and Curtis L. Johnson¹

¹Biomedical Engineering, University of Delaware, Newark, DE, United States, ²Mechanical Engineering and Material Science, Washington University in St. Louis, St. Louis, MO, United States, ³Thayer School of Engineering, Dartmouth College, Hanover, NH, United States, ⁴Mechanical Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States

The goal of this study is to thoroughly examine a novel customized multi-excitation MRE actuator combining both left-right (LR) and anterior-posterior (AP) drivers for use in estimating anisotropic mechanical properties of the brain. We demonstrate the key differences in wave patterns and how these lead to distinct stiffness estimations. The displacement fields from both excitations were combined to recover repeatable anisotropic properties in the corticospinal tract. The improved ME-MRE actuator can be used for future studies of white matter mechanical properties in health and disease.

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