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Abstract #1033

Quantitative Susceptibility Mapping (QSM) is Sensitive to Hippocampal and Subcortical Gray Matter Changes in Temporal Lobe Epilepsy

Oliver C. Kiersnowski1, Gavin P. Winston2,3, Emma Biondetti1,4, Sarah Buck2, Lorenzo Caciagli2,5, John Duncan2, Karin Shmueli1, and Sjoerd B. Vos6,7
1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Department for Clinical and Experimental Epilepsy, University College London, London, United Kingdom, 3Department of Medicine, Division of Neurology, Queen's University, Kingston, ON, Canada, 4Institut du Cerveau – ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France, 5Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 6Centre for Medical Image Computing, Computer Science Department, University College London, London, United Kingdom, 7Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

Although temporal lobe epilepsy (TLE) results in widespread changes in MRI measures of tissue volume, diffusion and functional connectivity, changes in tissue composition in TLE have not been investigated with MRI. Quantitative susceptibility mapping (QSM) is sensitive to changes in tissue composition, in particular to iron and myelin. Here, we show for the first time that QSM is sensitive to gray matter abnormalities in 31 patients with temporal lobe epilepsy (TLE) compared to 23 healthy controls, and showed significant susceptibility changes in the hippocampus in left TLE patients, and in the bilateral thalamus in both left and right TLE.

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