Abstract #1033

Quantitative Susceptibility Mapping (QSM) is Sensitive to Hippocampal and Subcortical Gray Matter Changes in Temporal Lobe Epilepsy

Oliver C. Kiersnowski¹, Gavin P. Winston^2,3, Emma Biondetti^1,4, Sarah Buck², Lorenzo Caciagli^2,5, John Duncan², Karin Shmueli¹, and Sjoerd B. Vos^6,7

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Department for Clinical and Experimental Epilepsy, University College London, London, United Kingdom, ³Department of Medicine, Division of Neurology, Queen's University, Kingston, ON, Canada, ⁴Institut du Cerveau – ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France, ⁵Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ⁶Centre for Medical Image Computing, Computer Science Department, University College London, London, United Kingdom, ⁷Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

Although temporal lobe epilepsy (TLE) results in widespread changes in MRI measures of tissue volume, diffusion and functional connectivity, changes in tissue composition in TLE have not been investigated with MRI. Quantitative susceptibility mapping (QSM) is sensitive to changes in tissue composition, in particular to iron and myelin. Here, we show for the first time that QSM is sensitive to gray matter abnormalities in 31 patients with temporal lobe epilepsy (TLE) compared to 23 healthy controls, and showed significant susceptibility changes in the hippocampus in left TLE patients, and in the bilateral thalamus in both left and right TLE.

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