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Abstract #1035

Association of hypometabolic extension of 18F-FDG PET with DTI in hippocampal sclerosis

Hiroyuki Tatekawa1, Hiroyuki Uetani1, Akifumi Hagiwara1, and Noriko Salamon1
1UCLA, Los Angeles, CA, United States

To assess associations between hypometabolic extensions of FDG PET and DTI, including MD and FA, 36 unilateral hippocampal sclerosis were stratified into broad hypometabolic (n=26) and localized groups (n=10) by the extension of FDG hypometabolism beyond or within the temporal lobe. Gray matter (GM) ROIs and TBSS were used to compare MD of GM and FA of white matter (WM) between hemispheres ipsilateral and contralateral to epilepsy focus. Associations between hypometabolism and DTI alterations, including more widespread GM abnormalities for broad than localized groups and significantly decreased FA in the temporal and frontal WM for broad group, were identified.

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