Abstract #1036

Analysis of Exchangeable Pool Contributions to the Chemical Exchange Saturation Transfer Signal Using a 2-stage Simulation Method

Qingqing Wen¹, Kang Wang², Yi-Cheng Hsu³, Yan Xu⁴, Yi Sun³, Dan Wu^1,2, and Yi Zhang^1,2

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Neurology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, ³MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁴Department of Neurosurgery, Zhejiang Provincial People's Hospital, HangZhou, China

A 2-stage simulation method was proposed to estimate the leading contributor to the CEST contrast between disease and normal tissues. First, the proposed method generates a best Bloch-McConnell fit to the MTR_asym spectra of the normal brain tissues. Second, it alters only one exchange parameter in the Bloch-McConnell model to fit the MTR_asym spectra of disease tissues each time. The candidate parameter that yields the smallest error between simulated and experimental results is identified as the leading contributor to the CEST contrast. The proposed method was validated in numeric phantoms and 9 tuberous sclerosis complex (TSC)-associated epilepsy patients.

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