Abstract #1037

Evaluating Brain Iron Content in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Kiarash Ghassaban^1,2, Chao Chai³, Huiying Wang⁴, Tong Zhang³, Jinxia Zhu⁵, Xianchang Zhang⁵, E. Mark Haacke^1,2, and Shuang Xia³

¹Department of Radiology, Wayne State University, Detroit, MI, United States, ²SpinTech, Inc., Bingham Farms, MI, United States, ³Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ⁴Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China, ⁵MR Collaboration, Siemens Healthcare Ltd, Beijing, China

Out of 29 idiopathic rapid eye movement behavior disorder (iRBD) patients and 28 age-matched healthy controls (HCs), 12 patients showed bilateral or unilateral loss of the N1 sign as opposed to two HCs with unilateral N1 loss. Additionally, both global and regional high susceptibility analyses showed significantly higher iron deposition in the right dentate nucleus (DN) along with significantly lower bilateral volume of the caudate nucleus in iRBD patients. These findings taken together with significant correlations between iron measurements and several cognitive and motor impairment scores may be indicative of biomarkers of an early neurodegenerative process in the iRBD patients.

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