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Abstract #1037

Evaluating Brain Iron Content in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Kiarash Ghassaban1,2, Chao Chai3, Huiying Wang4, Tong Zhang3, Jinxia Zhu5, Xianchang Zhang5, E. Mark Haacke1,2, and Shuang Xia3
1Department of Radiology, Wayne State University, Detroit, MI, United States, 2SpinTech, Inc., Bingham Farms, MI, United States, 3Department of Radiology, Tianjin First Central Hospital, Tianjin, China, 4Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China, 5MR Collaboration, Siemens Healthcare Ltd, Beijing, China

Out of 29 idiopathic rapid eye movement behavior disorder (iRBD) patients and 28 age-matched healthy controls (HCs), 12 patients showed bilateral or unilateral loss of the N1 sign as opposed to two HCs with unilateral N1 loss. Additionally, both global and regional high susceptibility analyses showed significantly higher iron deposition in the right dentate nucleus (DN) along with significantly lower bilateral volume of the caudate nucleus in iRBD patients. These findings taken together with significant correlations between iron measurements and several cognitive and motor impairment scores may be indicative of biomarkers of an early neurodegenerative process in the iRBD patients.

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