Meeting Banner
Abstract #1039

On the Spectrum of Dysmaturation of the Extremely Preterm Brain at Adolescence: Combined MS-qMRI Outcomes of the ELGAN-ECHO Study.

Ryan McNaughton1, Hernan Jara1,2, Chris Pieper2, Julie Rollins3, Osamu Sakai2, Laurie Douglass2, Rebecca Fry3, Karl Kuban2, and T. Michael O'Shea3
1Boston University, Boston, MA, United States, 2Boston University Medical Center, Boston, MA, United States, 3University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States

Purpose: To describe the spectrum of MS-qMRI outcomes in the extremely preterm (EP) brain at adolescence and identify relationships expressed as a result of dysmaturation. Methods: Quantitative MR algorithms create maps of the T1, T2, PD, and spatial entropy (SE) for 341 EP born individuals using MR images obtained with the Tri-TSE pulse sequence at age 15 years. Results: The EP brain exhibits linear relationships of T1 and PD with SE, and T2 with cerebrospinal fluid (CSF) volume. Conclusion: MS-qMRI of the EP brain provides a comprehensive quantification of dysmaturation states, from white matter structure to CSF composition.

This abstract and the presentation materials are available to members only; a login is required.

Join Here