Abstract #1039

On the Spectrum of Dysmaturation of the Extremely Preterm Brain at Adolescence: Combined MS-qMRI Outcomes of the ELGAN-ECHO Study.

Ryan McNaughton¹, Hernan Jara^1,2, Chris Pieper², Julie Rollins³, Osamu Sakai², Laurie Douglass², Rebecca Fry³, Karl Kuban², and T. Michael O'Shea³

¹Boston University, Boston, MA, United States, ²Boston University Medical Center, Boston, MA, United States, ³University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States

Purpose: To describe the spectrum of MS-qMRI outcomes in the extremely preterm (EP) brain at adolescence and identify relationships expressed as a result of dysmaturation. Methods: Quantitative MR algorithms create maps of the T1, T2, PD, and spatial entropy (SE) for 341 EP born individuals using MR images obtained with the Tri-TSE pulse sequence at age 15 years. Results: The EP brain exhibits linear relationships of T1 and PD with SE, and T2 with cerebrospinal fluid (CSF) volume. Conclusion: MS-qMRI of the EP brain provides a comprehensive quantification of dysmaturation states, from white matter structure to CSF composition.

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