Abstract #1040

Brain Function in Obesity: A Pilot Study to Assess Effects of Bariatric Surgery

Nareen Anwar¹, Wesley J Tucker², Nancy Puzziferri³, Jake Samuel², Vlad G Zaha³, Ildiko Lingvay³, Jaime Almandoz³, Jing Wang², Edward A Gonzales², Matthew Brothers², Michael Douglas Nelson², and Binu P Thomas^2,3

¹The University of Texas at Dallas, Richardson, TX, United States, ²The University of Texas at Arlington, Arlington, TX, United States, ³University of Texas Southwestern Medical Center, Dallas, TX, United States

Obesity is an ongoing epidemic that is associated with cognitive dysfunction and is a prominent precursor to a variety of neurogenerative diseases. Bariatric surgery is an effective and long-term weight loss strategy that can improve neurocognitive function. However, the mechanisms that drive these improvements are unknown. In this study, magnetic resonance imaging (MRI) is utilized to assess changes in cerebral metabolic rate of oxygen (CMRO₂) levels in bariatric surgery candidates before and after their surgery. These values are compared with normal healthy weight controls of a similar age and reassessed after 2 weeks and 14 weeks.

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