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Abstract #1043

Two patterns of cortical thickness relate to seizure relapse in pediatric patients with epilepsy after treatment

Wenjing Zhang1, Tao Yu2, Mengyuan Xu1, Chengmin Yang1, Naici Liu1, Su Lui1, and Haibo Qu3
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China, 3Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, National Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China

In the present study, a data-driven analysis of structural MRI data was conducted with pediatric epilepsy patients. We first resolve neurobiological heterogeneity based on neuroanatomical features, and then investigate the clinical relevance of using MRI data to predict seizure relapse status after treatment in each identified patient subgroup. Our study limits the influence of treatment and course of illness effects, potentially enhancing the ability to identify illness-specific biomarkers that delineate patient subgroups, and can also be used to evaluate the utility of such biomarkers in predicting illness progression and treatment response.

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