Abstract #1044

Cerebral Morphometric Alterations in Patients with Temporal Lobe Epilepsy related to Antero-inferior Temporal Meningoencephalocele

Laleh Eskandarian^1,2, Safak Parlak³, Gokce Ayhan⁴, Irsel Tezer⁴, Serap Saygi⁴, and Kader Karli Oguz^2,3

¹Neuroscience Department, Bilkent University, Ankara, Turkey, ²National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, ³Faculty of Medicine, Department of Radiology, Hacettepe University, Ankara, Turkey, ⁴Faculty of Medicine, Department of Neurology, Hacettepe University, Ankara, Turkey

This study investigates morphological alterations in patients with left temporal lobe epilepsy (TLE) due to ipsilateral antero-inferior temporal lobe meningoencephalocele (TLM). Compared with healthy control (HC)s, cortical thickness was increased extensively in both cerebral hemispheres with reduction in a few regions, most remarkably in the left temporal lobe. Both amygdala were significantly bigger in the patients compared with HCs. No difference was found in hippocampi and thalami between patients and HCs or between hemispheres within the patient group. No relation was found between these significant alterations and duration of disease.

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