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Abstract #1044

Cerebral Morphometric Alterations in Patients with Temporal Lobe Epilepsy related to Antero-inferior Temporal Meningoencephalocele

Laleh Eskandarian1,2, Safak Parlak3, Gokce Ayhan4, Irsel Tezer4, Serap Saygi4, and Kader Karli Oguz2,3
1Neuroscience Department, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 3Faculty of Medicine, Department of Radiology, Hacettepe University, Ankara, Turkey, 4Faculty of Medicine, Department of Neurology, Hacettepe University, Ankara, Turkey

This study investigates morphological alterations in patients with left temporal lobe epilepsy (TLE) due to ipsilateral antero-inferior temporal lobe meningoencephalocele (TLM). Compared with healthy control (HC)s, cortical thickness was increased extensively in both cerebral hemispheres with reduction in a few regions, most remarkably in the left temporal lobe. Both amygdala were significantly bigger in the patients compared with HCs. No difference was found in hippocampi and thalami between patients and HCs or between hemispheres within the patient group. No relation was found between these significant alterations and duration of disease.

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