Abstract #1046

T2 relaxometry and 18F-FDG-PET alterations in hippocampus and hippocampal subfields in left and right MR-negative temporal lobe epilepsy

Hui Huang¹, Miao Zhang², Wei Liu³, Jia Wang¹, Lihong Tang¹, Qikang Li¹, Biao Li², and Jie Luo¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Both PET and T2 relaxometry could provide complementary information of the epileptogenic zone, which could add value to presurgical planning of epilepsy patients. This study investigated evaluted the performance of hippocampual asymmetry measures from volumetry, T2 relaxometry and ¹⁸F-FDG PET in lateralization for MR negative left from right temporal TLE. We also investigated how hippocampal subfield alterations of T2 relaxometry and ¹⁸F-FDG-PET. Our experimental results showed the combination of T2 relaxometry and PET could complement each other in lateralization for MR-negative LTLE.

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