Abstract #1047

Proton MR spectroscopy reveals metabolic alterations in generalized tonic clonic seizures before and after treatment: a longitudinal study

Xinyue Wan¹, Xiaorui Su¹, Simin Zhang¹, Qiyong Gong¹, and Qiang Yue²

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Department of Radiology, West China Hospital of Sichuan University, Chengdu, China

The neurobiochemical mechanisms of Generalized tonic-clonic seizures (GTCS) patients' brains and the effects of antiepileptic drugs (AEDs) on metabolism are not yet clear. The purpose of this study was to use MRS to explore metabolic alterations of bilateral Dorsolateral prefrontal cortex (DLPFC) in pre-/post-treatment GTCS patients. We included 23 initially diagnosed GTCS patients and 23 healthy controls (HC). The metabolite level (n-acetyl aspartate, creatine) in DLPFC of GTCS patients was changed compared with that of healthy control, and AEDs had an effect on the metabolites concentration, which may explain the neurobiochemical mechanism.

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