Abstract #1048

Automated brain MRI volumetry and T1 relaxometry in children with focal epilepsy of unknown cause.

Baptiste MOREL^1,2, Anne Sophie Piegay¹, Maximilien Perivier¹, Sandra Obry¹, Bénédicte Maréchal^3,4,5, Gian Franco Piredda^3,4,5, Tom Hilbert^3,4,5, Tobias Kober^3,4,5, Clovis Tauber⁶, Pierre Castelnau⁶, and Jean Philippe Cottier¹

¹CHU de Tours, Tours, France, ²UMR 1253, iBrain, Université de Tours, INSERM, Tours, France, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁶INSERM U1253, Tours, France

In the initial exploration of children with focal epilepsy of unknown cause, MRI is useful. To increase the sensitivity of the MRI, we have defined a postprocessing Morphometric Analysis Program allowed obtaining automatically both volumetry and T1 relaxometry values in 38 brain regions. Deviations from reference ranges – previously established from a cohort of healthy subjects – help radiologists to quantify brain abnormalities undetected in brain MRI in more than 80% of our cases.

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