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Abstract #1048

Automated brain MRI volumetry and T1 relaxometry in children with focal epilepsy of unknown cause.

Baptiste MOREL1,2, Anne Sophie Piegay1, Maximilien Perivier1, Sandra Obry1, Bénédicte Maréchal3,4,5, Gian Franco Piredda3,4,5, Tom Hilbert3,4,5, Tobias Kober3,4,5, Clovis Tauber6, Pierre Castelnau6, and Jean Philippe Cottier1
1CHU de Tours, Tours, France, 2UMR 1253, iBrain, Université de Tours, INSERM, Tours, France, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 5LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 6INSERM U1253, Tours, France

In the initial exploration of children with focal epilepsy of unknown cause, MRI is useful. To increase the sensitivity of the MRI, we have defined a postprocessing Morphometric Analysis Program allowed obtaining automatically both volumetry and T1 relaxometry values in 38 brain regions. Deviations from reference ranges – previously established from a cohort of healthy subjects – help radiologists to quantify brain abnormalities undetected in brain MRI in more than 80% of our cases.

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