Abstract #1049

Neurochemical characteristics of pathological tissues in epilepsy: a 1H MRS study at 7T

Lijing Xin^1,2, Philippe Reymond³, José Boto³, Serge Vulliemoz⁴, Francois Lazeyras ⁵, and Maria Isabel Vargas³

¹CIBM Center for Biomedical Imaging, Lausanne, Switzerland, ²Animal Imaging and Technology, EPFL, Lausanne, Switzerland, ³Division of Neuroradiology, Diagnostic Department of Geneva University Hospitals and University of Geneva, Geneva, Switzerland, ⁴Division of Neurology, Neurosciences Department of Geneva University Hospitals and University of Geneva, Geneva, Switzerland, ⁵Center for Biomedical Imaging of Geneva and University of Geneva, Geneva, Switzerland

This study is aim to evaluate the neurochemical characteristics of pathological tissues by 1H MRS in patient with epilepsy at 7T. In comparison to the contralateral side, lesions in focal cortical dysplasia demonstrated significantly reduced macromolecule and N-acetyl aspartate, significantly increased total choline and glycine + myo-inositol, and a distinct reduction trend of glutamate. We conclude that performing MRS at high magnetic field offered the potential to reveal novel metabolic alterations in epilepsy lesions that may help to further understand the underlying pathophysiology of the disease.

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