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Abstract #1054

Sensitivity and Specificity of MRI Markers of Excess Manganese Brain Deposition

Humberto Monsivais1, Grace Francis2, Sandy Snyder1, Jonathan Kuhn3, and Ulrike Dydak1,4
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Department of Physics and Astronomy, Purdue University, West Lafayette, IN, United States, 3Mathematics and Statistics, Purdue University Northwest, Westville, IN, United States, 4Radiology and Imaging Scienes, Indiana University School of Medicine, Indianapolis, IN, United States

The pallidal index (PI) and the R1 relaxation rate are two commonly used MRI markers to diagnose manganese (Mn) neurotoxicity caused by excess Mn accumulation in the brain. While it has been hypothesized that the R1 relaxation rate is more sensitive and specific to Mn accumulation than the PI, a formal comparison is still missing. This study aimed to compare these two MRI markers' sensitivity and specificity to distinguish different levels of exposure to Mn by performing a receiver operating characteristic curve (ROC) analysis on a cohort of welders, occupationally exposed to Mn in welding fumes.

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