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Abstract #1055

UTE MRI can detect myelin loss in mice using an open field low intensity blast injury model of mild traumatic brain injury (mTBI)

Ya-Jun Ma1, Catherine E Johnson2, Jonathan Wong1,3, Hyungseok Jang1, Roland Lee1, Eric Y Chang1,3, Zezong Gu2, and Jiang Du1
1UC San Diego, San Diego, CA, United States, 2Missouri University of Science and Technology, Rolla, MO, United States, 3VA Health System, San Diego, CA, United States

Mild traumatic brain injury (mTBI) may cause significant myelin damage, leading to significant degradation of elaborate cognitive functions. However, conventional neuroimaging techniques are unable to accurately assess myelin, and fail to show abnormalities in the majority of mTBI cases. UTE MRI sequences with echo times (TEs) <0.1 ms allow direct imaging and quantitative assessment of myelin density. Here we aim to investigate whether the 3D IR-UTE sequence can detect myelin loss in mice using an open field low intensity blast injury model of mTBI. This technique provides a new approach for potentially more accurate diagnosis and treatment monitoring of mTBI.

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