Mild traumatic brain injury (mTBI) may cause significant myelin damage, leading to significant degradation of elaborate cognitive functions. However, conventional neuroimaging techniques are unable to accurately assess myelin, and fail to show abnormalities in the majority of mTBI cases. UTE MRI sequences with echo times (TEs) <0.1 ms allow direct imaging and quantitative assessment of myelin density. Here we aim to investigate whether the 3D IR-UTE sequence can detect myelin loss in mice using an open field low intensity blast injury model of mTBI. This technique provides a new approach for potentially more accurate diagnosis and treatment monitoring of mTBI.
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