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Abstract #1056

Topological reorganization due to repetitive head impacts: Insights from Professional Fighters Brain Health Study

Virendra R Mishra1, Karthik Sreenivasan1, Dietmar Cordes1, Aaron Ritter1, and Charles Bernick2
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Washington - Seattle, Seattle, WA, United States

Repetitive head impact (RHI) is thought to induce robust white-matter (WM) damage which may be the risk factor for various disorders. Though single-tensor diffusion MRI (dMRI) studies have improved our understanding of WM abnormalities at a regional level in participants exposed to RHI, there are no studies that attempt to understand topological WM structural connectivity changes due to RHI. Utilizing a high spatial resolution (1.5mm3) dMRI from 12 active male boxers and 10 demographically matched healthy controls (HC), we showed that RHI induces a topological shift as compared to HC, and this shift is correlated with neuropsychological scores.

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