Meeting Banner
Abstract #1057

Investigating the extent of difference in single tensor and beyond single tensor diffusion MRI-derived voxelwise measures

Virendra R Mishra1, Karthik Sreenivasan1, Dietmar Cordes1, Aaron Ritter1, and Charles Bernick2
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Washington - Seattle, Seattle, WA, United States

In this study, we investigated the spatial extent and location of white-matter (WM) disorganization due to repeated head impacts (RHI) by estimating single-tensor (ST) diffusion MRI (dMRI)-measures along with free-water (FW)-corrected ST measures, diffusion kurtosis imaging (DKI), and Neurite Orientation Dispersion and Density Imaging (NODDI) measures, along with understanding the correlation of such voxelwise measures with exposure to fighting and neuropsychological scores. Overall, our findings suggest that WM disorganization is prevalent in thalamocortical and corpus-callosum fibers due to RHI, although, the spatial extent and location of these differences are heavily dependent on the dMRI-models utilized in the study.

This abstract and the presentation materials are available to members only; a login is required.

Join Here