Meeting Banner
Abstract #1058

Hippocampal and Anterior Cingulate Blood Flow is Associated with Affective Symptoms in Chronic Traumatic Brain Injury

Binu P. Thomas1,2, Takashi Tarumi3,4, Ciwen Wang3, David C. Zhu5, Tsubasa Tomoto4, C. Munro Cullum3,6,7, Marisara Dieppa3, Ramon Diaz-Arrastia8, Kathleen Bell9, Christopher Madden6, Rong Zhang3,4, and Kan Ding3
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States, 3Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States, 5Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, United States, 6Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 8Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 9Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, United States

Chronic Traumatic-brain-injury (TBI) has lifelong implications on brain function. It is characterized by cerebral-blood-flow (CBF) deficits, often accompanied by TBI-related symptoms. It is crucial that we understand mechanisms of CBF alterations and its association with TBI-symptoms. We observed CBF deficits in patients with TBI in the thalamus, hippocampus and other subcortical structures compared to a group of normal control participants. Furthermore, CBF in the hippocampus and anterior cingulate were negatively associated with TBI-related symptoms of anxiety, depression, fatigue and sleep issues. Our results suggest that regional CBF deficits may be useful biomarkers for perfusion-targeted therapies to ameliorate TBI-related symptoms.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract