Abstract #1058

Hippocampal and Anterior Cingulate Blood Flow is Associated with Affective Symptoms in Chronic Traumatic Brain Injury

Binu P. Thomas^1,2, Takashi Tarumi^3,4, Ciwen Wang³, David C. Zhu⁵, Tsubasa Tomoto⁴, C. Munro Cullum^3,6,7, Marisara Dieppa³, Ramon Diaz-Arrastia⁸, Kathleen Bell⁹, Christopher Madden⁶, Rong Zhang^3,4, and Kan Ding³

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States, ³Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States, ⁵Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, United States, ⁶Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁸Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, ⁹Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, United States

Chronic Traumatic-brain-injury (TBI) has lifelong implications on brain function. It is characterized by cerebral-blood-flow (CBF) deficits, often accompanied by TBI-related symptoms. It is crucial that we understand mechanisms of CBF alterations and its association with TBI-symptoms. We observed CBF deficits in patients with TBI in the thalamus, hippocampus and other subcortical structures compared to a group of normal control participants. Furthermore, CBF in the hippocampus and anterior cingulate were negatively associated with TBI-related symptoms of anxiety, depression, fatigue and sleep issues. Our results suggest that regional CBF deficits may be useful biomarkers for perfusion-targeted therapies to ameliorate TBI-related symptoms.

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